Multipopulational transcriptomic analysis of high-risk beef cattle on arrival reveals genes and mechanisms which may predict bovine respiratory disease
Bovine respiratory disease (BRD) continues to impact beef cattle production. RNA-Seq has been employed to investigate host response and gene-by-environment regulatory function in cattle at arrival. Nevertheless, studies have been relatively underpowered, and findings remain disputed. Our objective was to analyze at-arrival blood transcriptomes from beef cattle in two populations to identify and corroborate BRD-predictive genes and mechanisms.