Determination of the milk pharmacokinetics and depletion of milk residues following intramammary administration of cephapirin sodium in lactating dairy goats

  • K. P. Hayman Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011
  • L. L. Timms Department of Animal Science, Iowa State University, Ames, IA 50011
  • J. P. Mochel Department of Biomedical Sciences, Iowa State University, Ames, IA 50011
  • P. J. Plummer Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011
  • P. J. Gorden Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA 50011
Keywords: intramammary cephapirin sodium, mastitis, dairy goats, antimicrobials, pharmacokinetics

Abstract

In the United States, between 2007 and 2017, the US Department of Agriculture’s National Agricultural Statistics Service reported dairy operations that had milk goats to be the fastest growing operations in the nation. The most impactful and economically important health challenge to dairy goat herds is mastitis. Currently, there are no labelled products for the treatment of mastitis in dairy goats and minimal research has been conducted to evaluate the pharmacokinetics of intramammary-administered antimicrobials. The objectives of this study were to determine the pharmacokinetics in milk of dairy goats treated with intramammary (IMM) cephapirin sodium and determine an appropriate withdrawal time for milk.

Published
2020-09-24
Issue
Section
Research Summaries

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