Pharmacokinetics of cannabidiolic acid in cattle following oral dosing of industrial hemp (Cannabis sativa)
Industrial hemp (IH) (Cannabis sativa containing <0.3% tetrahydrocannabinol [THC]) has gained recent traction as a novel agricultural commodity. Hemp plants and byproducts are considered to have nutritional and potentially therapeutic value. The presence of bioactive cannabinoid compounds including cannabidiol (CBD), cannabidiolic acid (CBDA), and 9-tetrahydrocannabolic acid (THCA-A) in hemp may result in drug residues in edible tissues that pose a food safety risk to the consumer. The absence of published data describing the pharmacokinetics of cannabinoids in livestock is a significant impediment to research.