A randomized control trial to evaluate propylene glycol alone or in combination with dextrose as a treatment for hyperketonemia in dairy cows

  • M. B. Capel Perry Veterinary Clinic, Perry, NY 14530
  • K. D. Bach College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
  • I. D. Knecht College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
  • K. J. Koebel College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
  • S. Mann College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
  • J. A. A. McArt College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
Keywords: intravenous dextrose, propylene glycol, hyperketonemic, hyperketonemic resolution, disease incidence, milk yield

Abstract

Postpartum dairy cows undergo a period of energy deficit that can lead to excessive lipolysis and formation of ketone bodies such as β-hydroxybutyrate (BHB). Cows that are hyperketonemic (HYK; blood [BHB] ≥1.2mmol/L) are at greater risk of adverse events during early lactation. Although 300 ml of oral propylene glycol (PG) has been shown to reduce these negative effects, the efficacy of intravenous (IV) dextrose is unclear. Our objective was to investigate the impact of IV dextrose as an adjunct therapy to PG on HYK resolution, disease incidence, and milk yield.

Published
2020-09-24
Issue
Section
Research Summaries