A randomized control trial to evaluate propylene glycol alone or in combination with dextrose as a treatment for hyperketonemia in dairy cows
Postpartum dairy cows undergo a period of energy deficit that can lead to excessive lipolysis and formation of ketone bodies such as β-hydroxybutyrate (BHB). Cows that are hyperketonemic (HYK; blood [BHB] ≥1.2mmol/L) are at greater risk of adverse events during early lactation. Although 300 ml of oral propylene glycol (PG) has been shown to reduce these negative effects, the efficacy of intravenous (IV) dextrose is unclear. Our objective was to investigate the impact of IV dextrose as an adjunct therapy to PG on HYK resolution, disease incidence, and milk yield.