Failure of a novel surface polysaccharide targeting vaccine to prevent Tritrichomonas foetus infection in beef cattle

Authors

  • T. B. Hairgrove Texas A&M AgriLife Extension Service, 241 D Kleberg TAMU 2471, College Station, TX 77843-2471
  • J. A. Thompson College of Veterinary Medicine and Biomedical Science, Texas A&M University College Station, TX 77843-4475
  • J. N. Rocha College of Veterinary Medicine and Biomedical Science, Texas A&M University College Station, TX 77843-4475
  • M. Vinacur Division of Infectious Diseases, Dept Medicine, Brigham and Women’s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
  • C. Roberts Texas A&M AgriLife Extension Service, 241 D Kleberg TAMU 2471, College Station, TX 77843-2471
  • G. B. Pier Division of Infectious Diseases, Dept Medicine, Brigham and Women’s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115
  • C. Cywes-Bentley Division of Infectious Diseases, Dept Medicine, Brigham and Women’s Hospital, Harvard Medical School, 181 Longwood Ave, Boston, MA 02115

DOI:

https://doi.org/10.21423/aabppro20208112

Keywords:

Tritrichomonas foetus, T. foetus, bovine trichomoniasis, immunization, pregnant cows

Abstract

Tritrichomonas foetus (T. foetus) is the causative agent of bovine trichomoniasis that has a major impact on production costs for beef cattle farmers. Immunization strategies to effectively protect against T. foetus are a high priority. T. foetus expresses a surface polysaccharide, beta 1-6 poly-Nacetyl glucosamine (PNAG). A PNAG-specific vaccine has demonstrated protection in pigs and horses. This study attempted to protect pregnant cows from an experimental T. foetus infection by prior vaccination with a PNAG-specific vaccine.

Cover image of the 53rd Conference Proceedings: A photo of a lone cow with a bell in a field.

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Published

2020-09-24

Issue

2020

Section

Research Summaries

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