Transcriptomic profiling of BRD-attributed mortality in stocker cattle identifies active inflammatory and antiviral pathways at arrival

  • Matthew A. Scott Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
  • Amelia R. Woolums Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
  • Cyprianna E. Swiderski Department of Clinical Sciences, Mississippi State University, Mississippi State, MS 39762
  • Andy D. Perkins Department of Computer Science and Engineering, Mississippi State University, Mississippi State, MS 39762
  • Bindu Nanduri Department of Basic Sciences, Mississippi State University College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762
  • David R. Smith Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
  • Brandi B. Karisch Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762
  • William B. Epperson Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS 39762
Keywords: bovine respiratory disease, whole blood transcriptomes, stocker cattle

Abstract

Diagnosis and management of bovine respiratory disease (BRD), the most significant disease complex in post-weaned beef cattle, relies predominantly upon nonspecific clinical signs. Research is necessary to discern the underlying biological processes associated with BRD acquisition and severity. We hypothesize that at-arrival whole blood transcriptomes of stocker cattle will distinguish host immunologic responses that influence BRD severity, defined by BRD-attributed mortality.

Published
2020-09-24
Issue
Section
Research Summaries