Genomic characterization of Salmonella Dublin recovered from Ohio cattle

Abstract

Multidrug-resistant (MDR) Salmonella enterica is a threat to animal and human health. Salmonella Dublin, a bovine-adapted S. enterica serotype, causes severe outbreaks among calves that frequently result in high mortality. Additionally, S. Dublin causes invasive infections in people, and the incidence of S. Dublin infections in people has been increasing over the past decade. Recovered isolates are frequently resistant to antimicrobials necessary for the treatment of invasive infections in calves and people. The transmission pathways of virulent Salmonella serotypes are not well characterized. Genomic characterization of recovered strains can be used to elucidate the genetic relatedness and identify potential routes of transmission. Therefore, the objective of this study as to characterize the genetic relatedness and genomic antimicrobial resistance determinants of S. Dublin recovered from cattle in Ohio.